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Frequently Asked Questions (FAQs)
You may have knee osteoarthritis if you experience one or more of the following common signs and symptoms:
- Joint soreness after overuse or inactivity
- Joint stiffness after resting or in the morning
- Pain when moving your knee
- Pain when using stairs or getting up from a chair
- Pain that prevents you from exercising your leg
- Grating or catching when moving your knee
- Joint pain that feels worse in the evening after a day's activity
- Deterioration of coordination due to pain and stiffness
- Weakened thigh muscles
Of course, as with any disease, you should be diagnosed with knee osteoarthritis by a doctor—so be sure to mention these signs and symptoms at your next appointment.More info
There are too many types of arthritis to list here. (For a complete list, go to arthritis.org.) Osteoarthritis, or OA, refers to the breakdown, or degeneration, of cartilage and fluid that cushion and lubricate the bones in your joints. Osteoarthritis can occur in any joint, but osteoarthritis of the knee is the most common type, affecting more than 10 million Americans.1More info
When you are diagnosed with knee osteoarthritis, the hyaluronic acid (HA) in the synovial fluid in your knee joint becomes diluted and breaks down—reducing its natural properties.2 This is associated with increased inflammatory processes that can degrade the cartilage in your knee.2 The inflammation causes pain receptors to begin firing during normal movement.2 The pain tends to cause knee osteoarthritis patients to limit movement, which in turn leads to further deterioration of joint structures and synovial fluid quality because movement is required for normal synovial homeostasis.More info
No, there are different classes of injectable therapies that may be used to treat osteoarthritis in your knee. For example, steroids (such as cortisone) will help relieve pain and swelling temporarily. And opioids (such as morphine) are a class of drug with a very strong analgesic (pain-killing) effect. However, neither steroids nor opioids treat the underlying cause of your knee osteoarthritis pain. On the other hand, viscosupplements like SUPARTZ are designed to replace the diseased synovial fluid in your knee joint, which provides cushioning and lubrication.More info
SUPARTZ is a non-surgical, non-pharmacologic therapy for knee osteoarthritis. SUPARTZ therapy can help relieve your pain, improve your mobility, and get you back to your normal activities.More info
- Proven pain relief across multiple clinical studies3,4
- As safe as saline in clinical studies3,5
- 280 million SUPARTZ injections administered worldwide6
- Flexible dosing so you only receive the number of shots that your doctor recommends
No drug or surgery is involved in SUPARTZ (other than a local anesthetic to numb your knee). You can schedule SUPARTZ treatments with your physician just as you would any other office visit. The whole procedure only takes a few minutes. Your doctor may advise you to avoid strenuous activities for a few days after your injection.More info
SUPARTZ treats knee osteoarthritis by temporarily replacing the diseased synovial fluid in your knee, which is an underlying cause of your pain.2 Unlike oral analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs) that affect all parts of your body, SUPARTZ specifically targets the osteoarthritis in your knee.More info
In clinical studies, adverse events were no more common following SUPARTZ therapy than following saline placebo.3,5 In fact, more people discontinued treatment with saline placebo than those who received SUPARTZ therapy.5 Pseudoseptic (acute inflammatory) reactions have NOT been reported in 20 prospective randomized controlled trials of SUPARTZ therapy.7 The FDA reviewed data on more than 8,000 patients prior to approving SUPARTZ in the United States.3More info
SUPARTZ may be the right treatment for you if:
- Your knee pain is due to osteoarthritis
- You are not getting adequate osteoarthritis knee pain relief from walking and/or physical therapy
- You are not getting adequate osteoarthritis knee pain relief from pain medications, including:
- Ibuprofen (e.g., Advil®)
- Acetaminophen (e.g., Tylenol®)
- Naproxen sodium (e.g., Aleve®)
SUPARTZ therapy is covered by Medicare and eligible for private plan coverage for the treatment of knee osteoarthritis. However, it may not be covered by your insurance. Each insurance carrier decides which (if any) viscosupplement product it will cover. Before initiating SUPARTZ therapy, call your insurance provider or have your doctor's office check on your behalf.More info
Most patients experience little or no discomfort during the injection.8 If you're concerned about the injection, talk to your doctor about ways to reduce any mild pain that may occur.More info
- Parmet S, Lynm C, Glass RM. Osteoarthritis of the knee. JAMA. 2003;289(8):1068.
- Balazs EA, Denlinger JL. Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol. 1993;20(suppl 39):3-9.
- SUPARTZ (package insert). Durham, NC: Bioventus LLC; 2012.
- Day R, Brooks P, Conaghan PG, Petersen M, Multicenter Trial Group. A double blind, randomized, multicenter, parallel group study of the effectiveness and tolerance of intraarticular hyaluronan in osteoarthritis of the knee. J Rheumatol. 2004;31(4):775-782.
- Strand V, Conaghan PG, Lohmander LS, et al. An integrated analysis of five double-blind, randomized controlled trials evaluating the safety and efficacy of a hyaluronan product for intra-articular injection in osteoarthritis of the knee. Osteoarthritis Cartilage. 2006;14(9):859-866.
- DOF 12000.19. Based on Seikagaku Corporation Annual Report; 2012.
- SUPARTZ file of prospective clinical studies. Regulatory file 29000.142.
- Shimizu M, Higuchi H, Takagishi K, et al. Clinical and biochemical characteristics after intra-articular injection for the treatment of osteoarthritis of the knee: prospective randomized study of sodium hyaluronate and corticosteroid. J Orthop Sci. 2010;15(1):51-56.